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Pages 215–236 from the book:Chapter 7. On-line derivatisation/degradation
Chapter Summary: Chemical or physical–chemical conversion, however, may be accomplished directly in the inlet system of a mass spectrometer (on-line). Such a procedure can permit the analysis of sub-microgram amounts of compound, which are accessible to mass spectrometric detection; it also saves time by eliminating the need for a separate derivatisation step.